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N Engl J Med 2010;362:1022–1029.[16] Waldvogel FA, Medoff G, Swartz MN

N Engl J Med 2010;362:1022–1029.[16] Waldvogel FA, Medoff G, Swartz MN. acnes may be a morefrequent etiologic agent of IAVO than is recognized. Relying on only one type of evidence, regard-less of its scientific rigor, is likely to result in an incomplete, incorrect, and biased base ofknowledge from which to judge clinical decisions (Dodd, 2007).

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For example, aserving of potato chips could be a bag, and a serving of fruit could be anorange. However, noneof the commonly recommended nonsurgical therapieshas been tested in randomized placebo-controlled trials(Wolff and Levine, 2002)

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